How to live longer -

[Newview01]

Become Amish. A specific kind of Amish too, apparently.

https://www.yahoo.com/news/amish-gen...214120783.html

Miami (AFP) - Scientists have found a genetic mutation in the Amish people of the midwestern United States that appears to make them live 10 years longer than people without it, a study said Wednesday.

The report in the journal Science Advances is the latest clue in a decade-plus search for the secrets to healthy aging in this traditional, Christian community that balks at most modern technology.

Researchers in the US and Japan are currently testing an experimental drug that aims to recreate the effect of this mutation in people, in the hopes it may protect against age-related illnesses and boost longevity.

"Not only do they live longer, they live healthier," said lead author Douglas Vaughan, chairman of medicine at Northwestern University Feinberg School of Medicine.

"It's a desirable form of longevity."

Researchers studied 177 members of the Berne Amish community in Indiana, and found 43 who had one mutant copy of the gene, SERPINE1.

These carriers lived to 85 on average, while those without it in the Amish community tend to live to 75.

Amish people with this gene mutation were also significantly less likely to get diabetes, and they had more efficient metabolisms.

The key protein at play in the aging of cells appears to be PAI-1 (plasminogen activator inhibitor,), which is influenced by SERPINE1.

PAI-1 is known to be related to aging in animals but its effect in humans has been less clear.

Northwestern University researchers have partnered with Japan's Tohoku University to develop and test an experimental drug that would inhibit the action of PAI-1, like in Amish people with the mutant gene.

The drug has passed basic safety trials and is now being tested in phase 2 trials in Japan on how well it works on insulin sensitivity in people type 2 diabetes and obesity.

Northwestern is seeking regulatory approval to begin a US trial next year.

[Twisted Canuck]

Huh. I wonder if it helps being Mennonite like my wife?
I'm pretty sure she is going to out live me.

But you know why most men die before their wife?

Because they want to.

It's a fact.

[muzzy]

So 76% of those Amish died like rest of us whooppee doo

[Twisted Canuck]

Pretty sure 100% of them are going to die like the rest of us....just a matter of when. Really, who wants to get that old and tired?

[4K3OGH]

Originally Posted by Twisted Canuck

Pretty sure 100% of them are going to die like the rest of us....just a matter of when. Really, who wants to get that old and tired?

they do die...but with a pretty bada** beard!

[Okotokian]

Soooo follow the Amish lifestyle. Great... more years added to a life devoid of drinking, smoking, dancing, fast cars, pre-marital whatever, and women dressed like Pilgrims. I think I'll pass.

Mind you, could leave the kids a lot of nice furniture....

[regl]

Originally Posted by Twisted Canuck

Pretty sure 100% of them are going to die like the rest of us....just a matter of when. Really, who wants to get that old and tired?

Ask yourself the same question when you reach 75.

[Twisted Canuck]

Originally Posted by Okotokian

Soooo follow the Amish lifestyle. Great... more years added to a life devoid of drinking, smoking, dancing, fast cars, pre-marital whatever, and women dressed like Pilgrims. I think I'll pass.

Mind you, could leave the kids a lot of nice furniture....

Bwahahaa.....post of the day! I will drink to that mon ami!

[Twisted Canuck]

Originally Posted by regl

Ask yourself the same question when you reach 75.

I can't think that far ahead. I'm 50 now, my dad passed at 76...I keep telling my kids to pray that a meteorite hits me in my tree stand before I'm old enough to need Depends. I'd like to go out in a huge flaming skid mark.

[EZM]

That mutation may be related to interbreeding. Amish populations don't normally "mix" with other genetic groups and there has been extensive relative and genetic issues present in much higher frequencies within these populations.

Not all mutations are "bad" - this is a perfect example where a mutation has caused longer life and could be deemed "desirable".

I wonder if this mutation is hereditary recessive in nature - I bet it might be.

[Twisted Canuck]

Originally Posted by EZM

That mutation may be related to interbreeding. Amish populations don't normally "mix" with other genetic groups and there has been extensive relative and genetic issues present in much higher frequencies within these populations.

Not all mutations are "bad" - this is a perfect example where a mutation has caused longer life and could be deemed "desirable".

I wonder if this mutation is hereditary recessive in nature - I bet it might be.

Inbreeding Bonus? Sweet.

[Newview01]

Originally Posted by EZM

That mutation may be related to interbreeding. Amish populations don't normally "mix" with other genetic groups and there has been extensive relative and genetic issues present in much higher frequencies within these populations.

Not all mutations are "bad" - this is a perfect example where a mutation has caused longer life and could be deemed "desirable".

I wonder if this mutation is hereditary recessive in nature - I bet it might be.

Or is this the last stand of a better genetic trait that is still being broken down?

[jtiwana]

Originally Posted by Okotokian

Soooo follow the Amish lifestyle. Great... more years added to a life devoid of drinking, smoking, dancing, fast cars, pre-marital whatever, and women dressed like Pilgrims. I think I'll pass.

Mind you, could leave the kids a lot of nice furniture....

best response ever lol

[Digger1]

Originally Posted by EZM

That mutation may be related to interbreeding. Amish populations don't normally "mix" with other genetic groups and there has been extensive relative and genetic issues present in much higher frequencies within these populations.

Not all mutations are "bad" - this is a perfect example where a mutation has caused longer life and could be deemed "desirable".

I wonder if this mutation is hereditary recessive in nature - I bet it might be.

Now Hillary is gonna be over there trying to get some...

[alacringa]

Why on earth would anyone want to live longer? Life sucks enough - who would want to draw it out. I'm hoping to be done before 50.

[Twisted Canuck]

Originally Posted by alacringa

Why on earth would anyone want to live longer? Life sucks enough - who would want to draw it out. I'm hoping to be done before 50.

C'mon now, 50? I'm 50! Give it until at least 70, trust me, 50 is too young.....

[58thecat]

Originally Posted by alacringa

Why on earth would anyone want to live longer? Life sucks enough - who would want to draw it out. I'm hoping to be done before 50.

Wow, sorry to hear that, got a date picked

My grandma turned 100 this summer, I tell ya she gets around, has many interesting stories based on real life situations to share, simply amazing.

[makin tracks]

best way to live longer in my opinion is






"Don't Die"

[EZM]

Originally Posted by Twisted Canuck

Inbreeding Bonus? Sweet.

Yup ........ there's hope for all the rednecks on here ..... lol ....

[EZM]

Originally Posted by Newview01

Or is this the last stand of a better genetic trait that is still being broken down?

Traits are different than mutations ..... and, if you are saying/insinuating this may relate to the people in the good book who lived for hundreds and hundreds of years and that this, in some way, presents some sort of scientific correlation to the same, then I guess we can link Steven Harper to the Aliens who assassinated Kennedy under the premise of protecting the secrets of Bigfoot and he co-conspired to lead the French revolution.

I'm not saying you are insinuating that, but that's kind of what I got reading into your comments.

Either way - That would be a pretty big stretch considering the mutation is well defined and isolated. It also appears to recessive and hereditary - not dominant and hereditary.

[Big Grey Wolf]

If you want to live longer " choose your parents wisely"