All bullets drop, all bullets are affected by wind. Some more than others. One thing I've realized over the last little while is paper ballistics of what a cartridge can and can't do don't mean much. You can give me the best ballistic 6.5mm out there and I could still miss a deer.
If a person doesn't get out and practise, get to know how a rifle performs, figure out real world bullet drops by actually shooting at those distances. Shooting in different conditions, learning to estimate distance and wind. All of these I think will make more of a difference than calibers.
As far as recoil goes, that all depends on the rifle. I've shot some 300win mags that a good recoil pad and stock design make it reasonable. I really couldn't tell much difference between the 708 that I started hunting with to the 308 that I shoot now. My brother said it best, " when you have a critter in your sights you're not thinking about recoil"
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