For me there is no science behind it. If it's bigger than a .243 and smaller than a 338 RUM, it is just fine. However, as I have aged, I have a gotten a bit smarter. Animals don't wear armor, and nothing can live with a hole in it's lungs. IMO, anything larger than a 308 is not really necessary. I will say that hunting is unpredictable, and so it is never a bad thing to carry as much gun as you can shoot accurately and comfortably. At this point in my life a 300 Win Mag is my upper limit.
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