I have met a pile of people over the years, trappers,farmers , recreational hunters, etc., that have a 12 gauge, .22 and a big game rifle , usually a 270, 308,303, or 30'06. The 30/30 as well but not as often.
They did/do quite well with them also.
But then, they are not saddled with the knowledge of rifles and ballistics , etc . that the rest of us are!
I could comfortably hunt big game anywhere in Alberta with my single shot .303 Brit
Cat