It depends on the situation and the weapon. There are times the movement/sound of chambering a round will kill your chance at a shot. I'm comfortable hunting with a round in the chamber and the safety on...have been hunting that way my whole life...but the weapon is in my hands and you'll never catch me with the barrel pointed at anything but the ground.
Some people will have accidents/kill themselves in the weirdest/silliest ways, many without any weapon at all.
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Common sense is so rare these days, that it should be considered a super power.
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