Fentanyl.
I go a little libertarian on this one. If you want to get high on opioids go ahead. If it ends up disastrous well that is on you. The biggest downfall of it that I see is accidental ingestion of fentanyl as a very small amount is dangerous. Make it legal in a pill form. That way it will be much harder to become accidentally ingested and will act as chlorine in the gene pool.
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When in doubt, use full throttle. It may not improve the situation, but it will end the suspense.
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