there is no magic wand to make a bad shot a good one.
a fatal shot will quickly stop the blood from pumping oxygen into the animals brain. ie, the large target area of the lungs and heart.
bullet construction can change the way a bullet will quickly fragment and cause large damage on impact or penetrate deeper into tissue before fragmenting and bust through possible bone or wide bodied animals.
a bigger caliber allows for a bigger bullet and more lead/copper and so more material to bust up and do damage.
but in the end, if the bullet, large or not, fragmenting or penetrating, is not aimed at the proper location of the animal, then the animal will only be injured and its other non-vital body functions will be destroyed resulting in potentially a long painful suffering.
all hunters owe it to the animal to make sure that their weapon is functioning properly and they have the skill to use it, the knowledge of the animals anatomy, and the patience to wait for a moment that is within their skill to deliver a well aimed sure-shot to the vital organs. And last but not least, the hunter must be prepared to get the meat out so that it is not spoiled by an unprepared hike out.
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