Why would you not be able to see the shot from the 22-250?
Even I can watch things fall with my 300WSM, I suspect there is more to this probelm than calibre choice.
BTW: 40gr. V-max's out of my 22-250 doing 3900fps, are flat and violent on varmints.
As for the fast and light Vs. slow and large, PM Bobby b and ask him about his soupped up 6 mm wildcat and 70 gr bullets on deer. But remember this is for guys who can place em, a bad placement into a bad place will get you in trouble.
I prefer to blend the situation sticking to bullets designed for big game, and keeping the speeds up.
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There are no absolutes
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