Is the rifle bedded? I had a similar problem with my 300 RUM. Went to tweak my 200 yd zero and all of a sudden I was completely off target. It just happened to be coincidence as it turned out to be a bedding issue. Corrected the bedding and the gun went back to half MOA. I dropped the barreled action into another stock and it shot great, so that's how I figured out it was the bedding.
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