Most of my "centerfire" shooting is with my .223, and in working-up loads for it... focussed on using Varget powder because of how temperature-sensitive it ISN'T. (screwy sounding sentence, sorry
) Main use~blasting groundhogs in 15C-30C+ spring and summer weather. I'd zero it in the early spring on a solid bench @ 100 yards with proper rests..then shoot prone off a bipod hunting in the spring/summer. I've never shot targets, or checked my grouping shooting prone when things warmed-up...but would consider it if I started missing my targets. Which basically never happens inside of 200 yards.
I'm getting some very interesting results using some very light, Hornady NTX I tested in LAST winter's coldest tempatures...and it looks like it'll be very cold before I'm back to finish that process. Maybe my 53s will take a back seat to the 35s if things work out! At least for this coming season. We'll see what happens to the first groundhog that gets one!