I have conversion 40 S&W barrels for both my Glock 20 & Glock 29 10mm's use it for cheap practice loads.
I wouldn't even consider anything less than the 10mm for defense against wild animals or for hunting.
and yes I know a 40S&W 180gr will go thru the chest/lungs of a black bear when it is being shot while trapped in a cage.
I also know of a fellow that emptied his Glock 20 10mm mag into a grizzly and it just ran off mind you I wouldn't carry a 10mm in grizzly country either...
I take this = 4.25" Ruger SRH in 454 Casull loaded with Beartooth 405gr WLNGC's @ 1330fps and yes that is a Crimson Trace laser grip...